“It’s just a huge potential space, and to be at the leading edge and focused on building those relationships is critical, she said. HOG HEARTS Pigs have long been a tantalizing source of transplants because their organs are so similar to humans. A hog heart at the time of slaughter, for example, is about the size of an adult human heart. websitesOther organs from pigs being researched for transplantation into humans include kidney, liver and lungs. Prior efforts at pig-to-human transplants have failed because of genetic differences that caused organ rejection or viruses that posed an infection risk. Swiss drugmaker Novartis AG folded its $1 billion xenotransplantation effort in 2001 because of safety concerns about pig viruses that could be passed to humans. George Church, a Harvard Medical School genetics professor and researcher, tackled that problem two years ago, using a new gene-editing tool known as CRISPR to trim away potentially harmful virus genes that have impeded the use of pig organs for transplants in humans. Church has since formed a company named eGenesis Bio to develop humanized pigs that do not provoke a rejection response or transfer viruses to people. The company last month raised $38 million in venture funding. Eventually, Church said, the process could enable researchers to harvest a dozen different organs and tissues from a single pig. Church estimates the first transplants involving humanized pig organs could occur in a clinical trial later this year, but these would only be used on people too sick to receive human organs.
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